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The roles of tyrosines 24, 31, and 60 in the high-affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor.

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J Biol Chem. The first sequence: Fred Sanger and insulin.

Genetics ; — A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. Stimulation of sulfate and thymidine incorporation into hypophysectomized rat cartilage by growth hormone and insulin-like growth factor-I in vitro: the somatomedin a legjobb öregedésgátló krém érzékeny bőrre revisited.

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The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. From insulin and insulin-like activity to the insulin superfamily of growth-promoting peptides: a 20th-century odyssey. Perspect Biol Med. Insulin-like growth factor-1 deficiency and metabolic syndrome. J Transl Med. Insulin-like growth factor system in cancer: novel targeted therapies.

Biomed Res Int. Hormone families: pancreatic hormones and homologous growth factors. Anti aging 280-nál ; — Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes. Endocrinol Metab Clin North Am. The insulin-like growth factors in adipogenesis and obesity. Anti aging 280-nál determinants for high-affinity binding of insulin-like growth factor II to insulin receptor IR -A, the exon 11 minus isoform of the IR. Mol Endocrinol.

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J Clin Endocrinol Metab. Endocrinology ; — The role of insulin-like growth factor binding proteins. Neuroendocrinology ; — Role of insulin-like growth factor binding proteins in controlling IGF öregedésgátló tippek dohányzó hírességektől. Mol Cell Endocrinol.

The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.

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Diabetes Metab Res Rev. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer ; — The IGF-I signaling pathway. Curr Pharm Des. Functional interplay between IGF-1 and adiponectin.

Int J Mol Sci. Estrogen regulation of growth hormone action.

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Endocr Rev. Insulin-like growth factors in the fed and fasted states. Involvement of insulin-like growth factor-I in the control of glucose homeostasis. Curr Opin Pharmacol.

Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial. Aging Cell ; 22— Cellular actions of the insulin-like growth factor binding proteins.

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The insulin-like growth factor system in obesity, insulin resistance and type 2 diabetes mellitus. J Clin Med. Exercise and circulating insulin-like growth factor I. Horm Res. Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise. Calcif Tissue Int. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy.

J Neurosci. Central insulin-like growth factor-1 IGF-1 restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline.

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Aging Cell ; — Role of IGF-I signaling in muscle bone interactions. Bone ; 79— Am J Physiol Endocrinol Metab. Diabetes ; — Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man. Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors.

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J Clin Invest. Growth hormone regulation of p85α expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Therapeutic aspects of growth hormone and insulin-like growth factor-I treatment on visceral fat and insulin sensitivity in adults. Diabetes Obes Metab. Increased P85α is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

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IGF-binding protein-2 protects against the development of obesity and insulin resistance. Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin β subunit. Impaired glucose homeostasis anti aging 280-nál insulin-like growth factor-binding proteintransgenic mice. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes.

Specific binding of human growth hormone but not insulin-like growth factors by human adipocytes. FEBS Lett.

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Nat Rev Endocrinol. Insulin-like growth factor I and growth hormone GH treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism.

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes.